Elucidating the role of 8q24 in colorectal cancer dating montage
We observed significant associations with colon cancer risk with markers rs13254738 (ordinal odds ratio, 0.82; 95% confidence interval, 0.072-0.94; P(trend) = 0.0037) and rs6983267 (ordinal odds ratio, 1.17; 95% confidence interval, 1.03-1.32, P(trend) = 0.013).
Survival analysis was done using a separate set of 460 cases to evaluate the clinical significance of these markers.
They then work to quickly translate those findings into treatment and prevention strategies.
Over the years of its history, the Cancer Center has made many important scientific advances including the development of a major classification scheme for lymphoma (Lukes), the discovery of the jun oncogene (Vogt), the elucidation of links between steroid hormones and breast and prostate cancer (Henderson, Ross, Pike, Bernstein, et al), the development of surgical techniques for orthotopic bladder reconstruction (Skinner), the establishment of the relationships between DNA methylation and cancer (Jones and Laird), the roles of glucose regulated proteins in cancer (Lee), the development of molecular markers for neuroblastoma (Seeger), bladder cancer (Cote), GI cancers (Lenz), 8q24’s link to prostate and colon cancer (Haiman, Henderson), and the identification of a key genetic mutation in lymphoma development (Lieber).
We also tested a subset of the 460 cases (n = 380) for structural abnormalities at or near the c-MYC locus using fluorescence in situ hybridization analysis.
Research USC Norris Comprehensive Cancer Center scientists work toward a complete understanding of the most fundamental aspects of cancer.
They study the abnormal cell growth characteristics of cancer to determine what goes wrong and how the process can be altered.
Molecular pathological epidemiology (MPE, also molecular pathologic epidemiology) is a discipline combining epidemiology and pathology.
It is defined as "epidemiology of molecular pathology and heterogeneity of disease".